Promising role of topical caffeine mesoporous gel in collagen resynthesis and UV protection through proline assessment

Abstract Background Caffeine, an alkaloid agent, has been globally used regularly in drinks, for the reduction skin cancers and wrinkle formation. As a result of previous, attempts have carried out to use caffeine cosmetology due its antioxidant UV ray protection effects. Our aim was evaluate effect on collagen resynthesis via proline prolidase biosynthesis mice, orally topically as mesoporous silica at three levels, influence protection. In biopsies treated following assessed using ELISA Western blot techniques, activity prolidase, together with concentrations proline, beta integrin, insulin growth factor, protein kinases beta, mitogen-activated kinase. Moreover, we loaded aforementioned parameters checkpoint kinase 1 Rad3-related protein. Results Caffeine promoted dose-dependent manner. The mechanism this process found level significantly increased enzyme activity. also had protective against exhibited by over-expression factor under-expression kinase, 1, Conclusions study revealed superiority SYL-C12 (mesoporous silica-loaded gel), compromising high independent factors, terms measured responses caffeine. significant apoptotic damage.